Most sensible advice I was ever given (and it was for my PA whatever it is certificate) was to wear appropriate gear.
He went on to say that if it is a hot day and you will be knapsacking for some time it is hardly appropriate to wear a full space suit. You might not get any spray on you, but you will die from heat exhaustion!.
I rarely wear any special clothing, just wellies really. If I get any spray on me (concentrate) I just wash it off straight away.
Pretty much every single knapsack I have ever used has resulted in my back getting wet, but it's never caused me any problems. Just be sensible and change your clothes as soon as practically possible.
I should point out that I have really only used weedkillers in a knapsack on any scale, such as Roundup. That won't hurt you. I've done a lot of paraquat spraying too. Nasty stuff but only if you start drinking it.
I expect it is the organophosphate insecticides that are going to do you harm more than anything. I doubt you will be using them on any scale, but if you do be a bit more careful. Don't get them on your skin, don't fill the sprayer more than 3/4 full, wear gloves and probably best to choose an alternative chemical.
If it is just Roundup, be sensible about it but it ain't going to do you any harm.
As for makes, unless it is a real nasty cheap chinese job then I expect they are much of a muchness. 20 litre is max capacity I would ever want on my back, and I would probably only put 15litres in anyway. The amount of foam still in there when you come to put the second lot in and you will only get 15 litres in anyway.
Get a good flat fan nozzle as well, they very often come with a crappy cone nozzle. Cone nozzles are for insecticides, not Roundup and the like.
Calibrate the sprayer properly, there are plenty of sites to show how if you google it. Don't just bung some in and hope for the best, it isn't good practice and is wasteful if nowt else.
Be realistic about it when you set your walking pace. Don't set off as iff you are in a race, use a pace you can keep up all day and if it is hilly ground you are doing don't come down at twice the speed you go up.
A lot of these things might not be critical, but you should at least know how to do the job properly. Whether you just bung a bit of chem in and waft the lance about afterwards is upto you, but at least learn the right way first. As I say, there are plenty of sites that give you the right way if you look.
edit: crikey! I went off on one a bit there.